Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats

István Leprán, Mátyás Koltai, Lászlo Szekeres

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted silk loop. It was found that each drug markedly increased the survival rate, reduced the occurrence of ventricular fibrillation and tachycardia, and delayed the appearance and shortened the duration of arrhythmias.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalEuropean Journal of Pharmacology
Volume69
Issue number2
DOIs
Publication statusPublished - Jan 16 1981

Keywords

  • Acetylsalicylic acid
  • Conscious rats
  • Indomethacin
  • Myocardial infarction
  • Sodium salicylate
  • Sulfinpyrazone

ASJC Scopus subject areas

  • Pharmacology

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