Effect of nifedipine treatment (imprinting) of rat feti and newborns on the responsiveness of adult rat's uterus. Extension of the imprinting theory

György Csaba, Csaba Kenéz, Csaba Karabélyos, Ottó Dobozy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

1. 1. The uterus of adult progeny of rats treated with nifedipine during the late phase of pregnancy react in vitro to oxytocin less and the contractility of ones treated with higher dose (100μg) disappears. 2. 2. There is a more pronounced deficiency or lack of responsiveness in five week old animals treated with nifedipine neonatally. 3. 3. The experiments demonstrate that perinatal imprinting can be developed not only on hormone receptors and enzymes but on ion (Ca2+) channels of the plasma membrane. Consideration of this fact might have an importance in clinical aspects too.

Original languageEnglish
Pages (from-to)533-536
Number of pages4
JournalGeneral Pharmacology
Volume26
Issue number3
DOIs
Publication statusPublished - May 1995

Keywords

  • Ca channels
  • contractility
  • imprinting
  • nifedipine
  • uterus

ASJC Scopus subject areas

  • Pharmacology

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