Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: Role of glutamic acid

E. Toth, H. Sershen, A. Hashim, E. Vízi, A. Lajtha

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

We studied the effect of local administration of nicotine on the release of monoamines in striatum, substantia nigra, cerebellum, hippocampus, cortex (frontal, cingulate), and pontine nucleus and on the release of glutamic acid in striatum of rats in vivo, using microdialysis for nicotine administration and for measuring extracellular amine and glutamic acid levels. Following nicotine administration the extracellular concentration of dopamine, increased in all regions except cerebellum; serotonin increased in cingulate and frontal cortex; and norepinephrine increased in substantia nigra, cingulate cortex, and pontine nucleus. Cotinine, the major nicotine metabolite, had no effect at similar concentrations. The cholinergic antagonists mecamylamine and atropine, the dopaminergic antagonists haloperidol and sulpiride, and the excitatory amino acid antagonist kynurenic acid all inhibited the nicotine-induced increase of extracellular dopamine in the striatum. The fact that kynurenic acid almost completely prevented the effects of nicotine, and nicotine at this concentration produced a 6-fold increase of glutamic acid release, suggests that the effect of nicotine is mainly mediated via glutamic acid release.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalNeurochemical Research
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 1992

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Microdialysis
Nicotine
Neurotransmitter Agents
Glutamic Acid
Brain
Gyrus Cinguli
Kynurenic Acid
Frontal Lobe
Substantia Nigra
Cerebellum
Dopamine
Mecamylamine
Cotinine
Excitatory Amino Acid Antagonists
Sulpiride
Dopamine Antagonists
Cholinergic Antagonists
Haloperidol
Metabolites
Atropine

Keywords

  • dopamine
  • glutamic acid
  • microdialysis
  • Nicotine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions : Role of glutamic acid. / Toth, E.; Sershen, H.; Hashim, A.; Vízi, E.; Lajtha, A.

In: Neurochemical Research, Vol. 17, No. 3, 03.1992, p. 265-271.

Research output: Contribution to journalArticle

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