Effect of neonatal interleukin-6 (IL-6) treatment (Hormonal imprinting) on the IL-6 content and localization of the peritoneal, blood and thymic cells of adult rats. A confocal microscopic analysis

György Csaba, Péter Kovács

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Single treatment of newborn rat with human recombinant interleukin-6 (IL-6) durably increases IL-6 content in certain cell types of the adult animal. Peritoneal mast cells contain a high quantity of IL-6, in contrast to controls which contain no IL-6. In addition, many other (mainly lymphatic) cells of the peritoneal fluid contain IL-6. However, IL-6 is present in the control thymocytes, in smaller amounts than in the neonatally IL-6 imprinted cells. In the blood, the number of IL-6 containing cells also increases after imprinting (lymphocytes and developing forms of mast cells).

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalCell biology international
Volume25
Issue number11
DOIs
Publication statusPublished - Jan 1 2001

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Keywords

  • Cytokines
  • Hormonal imprinting
  • IL-6
  • Interleukin-6
  • Lymphocytes
  • Mast cells

ASJC Scopus subject areas

  • Cell Biology

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