Effect of neonatal corticosterone treatment on brain monoamines and rearing activity in rats

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Abstract

Corticosterone given in a daily dose of 500 μg on the 3rd and 5th postnatal days led to an increased norepinephrine (NE) content in the hindbrain of adult rats of both sexes and resulted in an augmented rearing activity in novel environment. A dose of 300 μg was effective only in female rats. An increment in serotonin content of the same brain region could also be detected. The permanent effect of early postnatal corticosterone treatment on noradrenergic brain mechanisms was supported by the finding that the content of both 3H-NE and labelled NE metabolites was higher in several brain areas 16 hours after the intraventricular injection of 3H-NE as a result of steroid pretreatment.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume50
Issue number1
Publication statusPublished - 1977

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Corticosterone
Norepinephrine
Brain
Intraventricular Injections
Rhombencephalon
Therapeutics
Serotonin
Steroids

ASJC Scopus subject areas

  • Physiology

Cite this

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AB - Corticosterone given in a daily dose of 500 μg on the 3rd and 5th postnatal days led to an increased norepinephrine (NE) content in the hindbrain of adult rats of both sexes and resulted in an augmented rearing activity in novel environment. A dose of 300 μg was effective only in female rats. An increment in serotonin content of the same brain region could also be detected. The permanent effect of early postnatal corticosterone treatment on noradrenergic brain mechanisms was supported by the finding that the content of both 3H-NE and labelled NE metabolites was higher in several brain areas 16 hours after the intraventricular injection of 3H-NE as a result of steroid pretreatment.

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