Effect of neonatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone concentration in adult rat

E. Pap, G. Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Serum testosterone concentration was significantly elevated in adult male rats by a single perinatal allylestrenol administration. One week after a second allylestrenol treatment in adulthood the hormone concentration dropped below the control values. Serum progesterone concentration was significantly lowered in adult female rats by a single perinatal allylestrenol administration. Following a second allylestrenol treatment in adulthood the hormone concentration reached the control values. These experiments demonstrate that the hormonal imprinting caused by allylestrenol (a steroid used in the treatment of endangered pregnancy) not only acts at receptor level and produces changes in sexual behaviour, but also induces modifications in serum hormone concentrations.

Original languageEnglish
Pages (from-to)1249-1251
Number of pages3
JournalReproduction, Fertility and Development
Volume7
Issue number5
DOIs
Publication statusPublished - 1995

Fingerprint

Allylestrenol
genomic imprinting
testosterone
Progesterone
Testosterone
progesterone
hormones
adulthood
rats
Serum
Hormones
sexual behavior
steroids
pregnancy
receptors
Sexual Behavior
Steroids
Imprinting (Psychology)
Pregnancy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Reproductive Medicine
  • Developmental Biology
  • Endocrinology

Cite this

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AU - Csaba, G.

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