Effect of monoamine oxidase inhibitors on rat paw edema induced by various phlogistic agents

M. Fekete, A. Marianne Kürti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of monoamine oxidase (MAO) inhibitors, tranylcypromine, nialamide and AB-15 (1-meta-amino-phenyl-(2-cyclopropylamino)-ethanol.2HCl) were investigated on rat paw edema induced by dextran, carrageenin, kaolin, yeast and formalin. Edema formation induced by dextran, kaolin and carrageenin was increased in rats pretreated with the enzyme inhibitors. The yeast edema was potentiated only by AB-15. Methysergide inhibited edema, with the exception of that induced by kaolin, and reversed the effect of the MAO inhibitors. The inhibition by reserpine of the inflammatory reactions was partly reversed by the MAO blocking agents. The results are discussed in view of a possible role of serotonin and catecholamines in the types of edema investigated.

Original languageEnglish
Pages (from-to)268-276
Number of pages9
JournalEuropean Journal of Pharmacology
Volume10
Issue number2
DOIs
Publication statusPublished - May 1970

Keywords

  • Catecholamine metabolism
  • Inflammation
  • MAO inhibitors
  • Rat paw edema
  • Reserpine
  • Serotonylytics

ASJC Scopus subject areas

  • Pharmacology

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