Effect of molluscan neuropeptide RAPYFVamide on identified Helix pomatia L. neurons

T. Kiss, Oleg N. Osipenko

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. The effect of Mytilus inhibitory peptide-related peptide RAPYFVamide, isolated from Helix pomatia brain, was studied on 21 different identified Helix neurons. 2. It was found that the neuropeptide hyperpolarized 11 of the 21 neurons studied, inducing a K-dependent current. Not all neurons responded by hyperpolarization to the peptide application, though, in all cases the voltage dependent outward K and inward Ca currents were depressed, 3. This may show that, in the peptide effect, more than one type of K conductance is involved, 4. It is proposed that RAPYFVamide may have a functional role in the modulation of the feeding behavior in H. pomatia.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalGeneral Pharmacology
Volume29
Issue number1
DOIs
Publication statusPublished - Jul 1997

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Neuropeptides
Neurons
Peptides
Feeding Behavior
Brain
arginyl-alanyl-prolyl-tyrosyl-phenylalanyl-valinamide

Keywords

  • Ca-curent
  • K-current
  • Neuropeptide
  • Snail neuron

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of molluscan neuropeptide RAPYFVamide on identified Helix pomatia L. neurons. / Kiss, T.; Osipenko, Oleg N.

In: General Pharmacology, Vol. 29, No. 1, 07.1997, p. 97-102.

Research output: Contribution to journalArticle

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