Effect of mitochondrial toxins on evoked somatosensory activity in rats

Szabolcs Takács, Sarolta Bankó, A. Papp

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mitochondrial toxins represent an interesting group of neurotoxicants related both to causation and modelling of central nervous damage. 3-nitropropionic acid (3NP), a neurotoxin of herbal and microfungal origin, inhibits succinate dehydrogenase leading thereby to various biochemical and morphological alterations in the brain. Experimental animals treated by 3NP are used to model Huntington's disease. Manganese, often present in occupational settings and as environmental pollutant, inhibits complex II and III of the mitochondria and is known to cause Parkinson-like CNS damage. In this work, rats were administered a single acute dose of Mn (50 mg Mn2+/kg body weight) or 3-NP (20 mg/kg b. w.) and the alterations of the somatosensory cortical evoked potential elicited by stimulation of the whisker pad and the tail base were observed, together with the changes of the action potential in the tail nerve. Latency and amplitude of the two cortical responses changed in parallel, while those of the tail nerve response remained more or less unaltered. The two mitochondrial toxins studied seem to exert their action centrally, primarily on synaptic transmission, rather than peripherally. Recording of evoked activity could be used to follow-up the nervous system effects of mitochondrial toxins, but it requires further investigation.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalCentral European Journal of Biology
Volume5
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint

3-nitropropionic acid
Tail
Rats
tail
toxins
Environmental Pollutants
succinate dehydrogenase (quinone)
Mitochondria
Succinate Dehydrogenase
rats
Bioelectric potentials
Neurotoxins
nerve tissue
Neurology
Manganese
Vibrissae
Brain
synaptic transmission
Animals
evoked potentials

Keywords

  • Evoked potential
  • Mitochondrial toxin
  • Nerve action potential
  • Neurotoxicity
  • Rat

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Effect of mitochondrial toxins on evoked somatosensory activity in rats. / Takács, Szabolcs; Bankó, Sarolta; Papp, A.

In: Central European Journal of Biology, Vol. 5, No. 3, 2010, p. 293-298.

Research output: Contribution to journalArticle

Takács, Szabolcs ; Bankó, Sarolta ; Papp, A. / Effect of mitochondrial toxins on evoked somatosensory activity in rats. In: Central European Journal of Biology. 2010 ; Vol. 5, No. 3. pp. 293-298.
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