Effect of methicillin on the phospholipid content of methicillin sensitive Staphylococcus aureus.

F. Rozgonyi, J. Kiss, P. Jékel, L. Váczi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of methicillin at concentrations of 1 microgram/ml (= 1/2 x minimum inhibitory concentration) and 2 microgram/ml (= 1 x MIC) on the phospholipid content of methicillin-sensitive Staphylococcus aureus 5814S growing exponentially were studied. During 2-hour treatment 1/2 x MIC of methicillin induced a significant increase in the phospholipid content of the cocci; accumulation of acid phospholipids was prevalent. In contrast, addition of 1 x MIC of methicillin to the cultures resulted in significantly less phospholipids in the cocci compared with that of the control cultures. There were some alterations in the amounts of individual phospholipids during treatment. The phosphatidic acid (PA) and diphosphatidylglycerol--cardiolipin (DPG) contents were significantly reduced in the first hour then reached the control values by the end of the 2nd hr of exposure. An opposite change was found in the amount of lysylphosphatidylglycerol (LPG), whereas the phosphatidylglycerol (PG) level was significantly lower in the treated cultures than in the controls of corresponding age. Phospholipid synthesis seems to be one of the sites of the action of methicillin in S. aureus.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume27
Issue number1
Publication statusPublished - 1980

Fingerprint

Methicillin
Staphylococcus aureus
Phospholipids
Cardiolipins
Phosphatidylglycerols
Phosphatidic Acids
Microbial Sensitivity Tests
Acids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of methicillin on the phospholipid content of methicillin sensitive Staphylococcus aureus. / Rozgonyi, F.; Kiss, J.; Jékel, P.; Váczi, L.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 27, No. 1, 1980, p. 31-40.

Research output: Contribution to journalArticle

@article{ef8916ed968142a7ba55835cd8e78d05,
title = "Effect of methicillin on the phospholipid content of methicillin sensitive Staphylococcus aureus.",
abstract = "The effects of methicillin at concentrations of 1 microgram/ml (= 1/2 x minimum inhibitory concentration) and 2 microgram/ml (= 1 x MIC) on the phospholipid content of methicillin-sensitive Staphylococcus aureus 5814S growing exponentially were studied. During 2-hour treatment 1/2 x MIC of methicillin induced a significant increase in the phospholipid content of the cocci; accumulation of acid phospholipids was prevalent. In contrast, addition of 1 x MIC of methicillin to the cultures resulted in significantly less phospholipids in the cocci compared with that of the control cultures. There were some alterations in the amounts of individual phospholipids during treatment. The phosphatidic acid (PA) and diphosphatidylglycerol--cardiolipin (DPG) contents were significantly reduced in the first hour then reached the control values by the end of the 2nd hr of exposure. An opposite change was found in the amount of lysylphosphatidylglycerol (LPG), whereas the phosphatidylglycerol (PG) level was significantly lower in the treated cultures than in the controls of corresponding age. Phospholipid synthesis seems to be one of the sites of the action of methicillin in S. aureus.",
author = "F. Rozgonyi and J. Kiss and P. J{\'e}kel and L. V{\'a}czi",
year = "1980",
language = "English",
volume = "27",
pages = "31--40",
journal = "Acta Microbiologica et Immunologica Hungarica",
issn = "1217-8950",
publisher = "Akademiai Kiado",
number = "1",

}

TY - JOUR

T1 - Effect of methicillin on the phospholipid content of methicillin sensitive Staphylococcus aureus.

AU - Rozgonyi, F.

AU - Kiss, J.

AU - Jékel, P.

AU - Váczi, L.

PY - 1980

Y1 - 1980

N2 - The effects of methicillin at concentrations of 1 microgram/ml (= 1/2 x minimum inhibitory concentration) and 2 microgram/ml (= 1 x MIC) on the phospholipid content of methicillin-sensitive Staphylococcus aureus 5814S growing exponentially were studied. During 2-hour treatment 1/2 x MIC of methicillin induced a significant increase in the phospholipid content of the cocci; accumulation of acid phospholipids was prevalent. In contrast, addition of 1 x MIC of methicillin to the cultures resulted in significantly less phospholipids in the cocci compared with that of the control cultures. There were some alterations in the amounts of individual phospholipids during treatment. The phosphatidic acid (PA) and diphosphatidylglycerol--cardiolipin (DPG) contents were significantly reduced in the first hour then reached the control values by the end of the 2nd hr of exposure. An opposite change was found in the amount of lysylphosphatidylglycerol (LPG), whereas the phosphatidylglycerol (PG) level was significantly lower in the treated cultures than in the controls of corresponding age. Phospholipid synthesis seems to be one of the sites of the action of methicillin in S. aureus.

AB - The effects of methicillin at concentrations of 1 microgram/ml (= 1/2 x minimum inhibitory concentration) and 2 microgram/ml (= 1 x MIC) on the phospholipid content of methicillin-sensitive Staphylococcus aureus 5814S growing exponentially were studied. During 2-hour treatment 1/2 x MIC of methicillin induced a significant increase in the phospholipid content of the cocci; accumulation of acid phospholipids was prevalent. In contrast, addition of 1 x MIC of methicillin to the cultures resulted in significantly less phospholipids in the cocci compared with that of the control cultures. There were some alterations in the amounts of individual phospholipids during treatment. The phosphatidic acid (PA) and diphosphatidylglycerol--cardiolipin (DPG) contents were significantly reduced in the first hour then reached the control values by the end of the 2nd hr of exposure. An opposite change was found in the amount of lysylphosphatidylglycerol (LPG), whereas the phosphatidylglycerol (PG) level was significantly lower in the treated cultures than in the controls of corresponding age. Phospholipid synthesis seems to be one of the sites of the action of methicillin in S. aureus.

UR - http://www.scopus.com/inward/record.url?scp=0018881860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018881860&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 31

EP - 40

JO - Acta Microbiologica et Immunologica Hungarica

JF - Acta Microbiologica et Immunologica Hungarica

SN - 1217-8950

IS - 1

ER -