The authors elaborate on their results following delivery of 418 women with epilepsy. Out of 429 newborns 44 were born with congenital malformations (10.3%), 16 (3.7%) being major and 28 (6.5%) being minor anomalies. In case of monotherapy the ratio of congenital malformations was 10.9%, in case of multiple drug use 14.14% - whereas in cases of no treatment given it was 4.1%. It is remarkable that in cases of major congenital birth defects 5 women were on valproic acid monotherapy during pregnancy. The rate of premature deliveries was 8.4%, that of dysmaturity 6,8%. There were no differences found in the anthropometric parameters of newborns delivered by women on mono-, polytherapy or no therapy. The authors state that even in case of women suffering from epilepsy it is possible to achieve perinatal mortality and premature birth rates alike the normal, healthy population. With preconceptional care, correct drug therapy, timely folic acid and vitamin K substitution and regular follow-up of the newborns of epileptic mothers enable these babies to have similar chances in their life-expectancy as their healthy counterparts.
|Translated title of the contribution||Effect of maternal antiepileptic treatment on the intrauterine fetus and newborn|
|Number of pages||10|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2002|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology