Effect of lymphokine on the activation and Fc receptor expression of rat macrophages

B. Dezső, Mátyás Hauck, Gabriella Fóris

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Lymphocyte supernatant (LS) containing lymphokine (LK) activated rat peritoneal macrophages (PM) and at the same time enhanced their Fc receptor (FcR) activity. The signs of the early activation could not be observed on alveolar macrophages (AM) but the augmented FcR expression occurred under the effect of lymphokine. The LK-induced macrophage activation and the enhancement of erythrocyte-antibody (EA) rosette formation were found to be independent of each other. In the presence of soybean trypsin inhibitor (STI) the crude lymphokine-induced augmented EA rosette formation was only slightly diminished. However, it did not seem likely that the LK components of molecular weight over 15,000 could enhance the number of rosettes under the effect of protease inhibitor. These data indicate that the macrophage proteases play an important role in the generation of EA rosette formation enhancing breakbown product(s) during the macrophage-lymphokine interaction.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalImmunology Letters
Volume3
Issue number2
DOIs
Publication statusPublished - 1981

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Fc Receptors
Lymphokines
Macrophages
Rosette Formation
Antibody Formation
Erythrocytes
Trypsin Inhibitors
Macrophage Activation
Alveolar Macrophages
Peritoneal Macrophages
Protease Inhibitors
Soybeans
Peptide Hydrolases
Molecular Weight
Lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effect of lymphokine on the activation and Fc receptor expression of rat macrophages. / Dezső, B.; Hauck, Mátyás; Fóris, Gabriella.

In: Immunology Letters, Vol. 3, No. 2, 1981, p. 87-91.

Research output: Contribution to journalArticle

Dezső, B. ; Hauck, Mátyás ; Fóris, Gabriella. / Effect of lymphokine on the activation and Fc receptor expression of rat macrophages. In: Immunology Letters. 1981 ; Vol. 3, No. 2. pp. 87-91.
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