Effect of low-pathogenicity influenza virus H3N8 infection on Mycoplasma gallisepticum infection of chickens

L. Stipkovits, L. Egyed, V. Pálfi, Andrea Beres, Ervin Pitlik, Maria Somogyi, Susan Szathmary, B. Dénes

Research output: Contribution to journalArticle

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Abstract

Mycoplasma infection is still very common in chicken and turkey flocks. Several low-pathogenicity avian influenza (LPAI) viruses are circulating in wild birds that can be easily transmitted to poultry flocks. However, the effect of LPAI on mycoplasma infection is not well understood. The aim of the present study was to investigate the infection of LPAI virus H3N8 (A/mallard/Hungary/19616/07) in chickens challenged with Mycoplasma gallisepticum. Two groups of chickens were aerosol challenged with M. gallisepticum. Later one of these groups and one mycoplasma-free group were aerosol challenged with the LPAI H3N8 virus. The birds were observed for clinical signs for 8 days, then euthanized, and examined for the presence of M. gallisepticum in the trachea, lung, air sac, liver, spleen, kidney and heart, and for developing anti-mycoplasma and anti-viral antibodies. The LPAI H3N8 virus did not cause any clinical signs but M. gallisepticum infection caused clinical signs, reduction of body weight gain and colonization of the inner organs. These parameters were more severe in the birds co-infected with M. gallisepticum and LPAI H3N8 virus than in the group challenged with M. gallisepticum alone. In addition, in the birds infected with both M. gallisepticum and LPAI H3N8 virus, the anti-mycoplasma antibody response was reduced significantly when compared with the group challenged with M. gallisepticum alone. Co-infection with LPAI H3N8 virus thus enhanced pathogenesis of M. gallisepticum infection significantly.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalAvian Pathology
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Mycoplasma gallisepticum
Mycoplasma Infections
Virus Diseases
Influenza in Birds
Orthomyxoviridae
H3N8 Subtype Influenza A Virus
Virulence
Chickens
pathogenicity
Influenza A virus
avian influenza
chickens
infection
Birds
Mycoplasma
mycoplasmosis
aerosols
Aerosols
Anti-Idiotypic Antibodies
birds

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Animals
  • Immunology and Microbiology(all)

Cite this

Effect of low-pathogenicity influenza virus H3N8 infection on Mycoplasma gallisepticum infection of chickens. / Stipkovits, L.; Egyed, L.; Pálfi, V.; Beres, Andrea; Pitlik, Ervin; Somogyi, Maria; Szathmary, Susan; Dénes, B.

In: Avian Pathology, Vol. 41, No. 1, 02.2012, p. 51-57.

Research output: Contribution to journalArticle

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