The effect of low-dose (2-4 μg>/kg>/min) and long-term (≥46 h) dopamine infusion on serum prolactin and thyrotropin concentrations was investigated in 8 preterm infants with hyaline membrane disease. Dopamine was administered for systemic hypotension and/or for impending renal failure. Serum prolactin decreased from 1.314.5 ± 422.7 μU/ml to 489.9 ± 464.1 μU/ml (p < 0.005), while serum thyrotropin fell from 3.77 ± 2.27μU/ml to 1.01 ± 0.25 μU/ml (p < 0.025) during dopamine infusion. Our data indicate that exogenous dopamine exerts an inhibitory effect on the secretion of prolactin and thyrotropin even in the sick preterm neonate. The role of prolactin in fetal lung maturation and in regulation of the neonatal tissue water stores is discussed. The results of the present study are also useful in explaining the renal effects of long-term low-dose dopamine infusion in the sick preterm infant.
- Hyaline membrane disease
- Preterm infant
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology