Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats

C. Nyakas, Bauke Buwalda, Paul G M Luiten, Béla Bohus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In young Wistar rats conditioned emotional stress can be characterized by a learned bradycardiac response to an inescapable footshock. In aged rats this bradycardiac response is attenuated and accompanied by suppressed behavioral arousal in response to novelty. In the present study, cardiac responses to emotional stress and behavioral reactivity to a novel experience in an open field were tested in aged and young rats under the influence of a low dose of d-amphetamine (AMPH, 0.5 mg/kg IP). AMPH administration in 27-month-old rats reinstated the bradycardiac response to emotional stress, while it failed to influence the resting heart rate in the home cage. Age-associated differences in open-field ambulation, present in drug-free conditions, were antagonized by low doses of AMPH (0.25-1.0 mg/kg). It is concluded that enhanced arousal by aminergic stimulation with AMPH in the aged rat invoked cardiac and behavioral response patterns resembling those at younger ages.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalNeurobiology of Aging
Volume13
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Amphetamine
Psychological Stress
Arousal
Dextroamphetamine
Walking
Wistar Rats
Heart Rate
Pharmaceutical Preparations

Keywords

  • Aging
  • Amphetamine
  • Behavioral arousal
  • Bradycardiac response
  • Stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats. / Nyakas, C.; Buwalda, Bauke; Luiten, Paul G M; Bohus, Béla.

In: Neurobiology of Aging, Vol. 13, No. 1, 1992, p. 123-129.

Research output: Contribution to journalArticle

Nyakas, C. ; Buwalda, Bauke ; Luiten, Paul G M ; Bohus, Béla. / Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats. In: Neurobiology of Aging. 1992 ; Vol. 13, No. 1. pp. 123-129.
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