Effect of long term feeding of T-2 and HT-2 toxin contaminated diet on the glutathione redox status and lipid peroxidation processes in common carp (Cyprinus carpio L.)

Krisztián Balogh, Mónika Heincinger, Judit Fodor, Miklós Mézes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Effect of sublethal T-2 (2.45 mg kg-1 feed) and HT-2 (0.52 mg kg-1 feed) toxin treatment for 4 weeks was investigated in common carp. Two groups, a control and a T-2+HT-2 toxin treated were formed. Six carps were exterminated from each group weekly. Liver samples were taken, in which reduced glutathione concentration and glutathione-peroxidase activity were measured. Free radical formation was measured by a direct reactive oxygen metabolites test, and also malondialdehyde concentration was determined. From the first week lower feed consumption and weight gain was recorded in T-2 toxin treated group, which resulted significantly lower live weight at the end of experiment. Feeding the T-2 toxin contaminated diet caused, significantly elevated glutathione concentration and glutathione-peroxidase activity during the first week. At second week the T-2 toxin loading resulted decrease in glutathione concentration and glutathione-peroxidase activity of liver as compared to the control. Although the reactive oxygen metabolite concentration was elevated in T-2 toxin treated group during the first t w o weeks, no significant changes were found in the MDA concentration. The results show that the biological antioxidant system was able to eliminate the harmful peroxidative effect of T-2 toxin in common carp.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalActa Biologica Szegediensis
Volume53
Issue numberSUPPL. 1
Publication statusPublished - Dec 1 2009

Keywords

  • Common carp
  • Glutathioe redox system
  • Lpid peroidaiintroduction
  • T-2 toxin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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