Effect of lipoproteins on aldosterone production by isolated glomerulosa cells

Károly nagy, László Koroknai, András Spät

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have studied the effects of human high density and low density lipoproteins on adrenocorticotropin (ACTH)-induced aldosterone production by isolated glomerulosa cells obtained from lipoprotein-deficient rats. ACTH increased basal aldosterone production, and the addition of either lipoprotein fraction further enhanced ACTH-induced aldosterone production. This increase could be shown at physiological lipoprotein-cholesterol concentrations. These data are compatible with a role of both high density and low density lipoproteins in supplying cholesterol to aldosterone-secreting glomerulosa cells.

Original languageEnglish
Pages (from-to)789-791
Number of pages3
JournalJournal of Steroid Biochemistry
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 1984

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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