Effect of ligands on Drosophila phosphorylase a as monitored by its enzymic inactivation

Research output: Contribution to journalArticle

Abstract

1. 1. The dephosphorylation of Drosophila phosphorylase a with the catalytic subunit of fruit-fly protein phosphatase-1 was inhibitied by AMP, IMP, ADP, ATP, glucose-6-P, glucose-1-P and UDPG. Glucose, caffeine and glycogen did not influence the reaction. 2. 2. The inhibitory effect of AMP was reduced by glucose and caffeine. 3. 3. The above ligands acted through the modification of phosphorylase a conformation. This conclusion was drawn from the ligands' effect on the dephosporylation of phosphohistone by Drosophila phosphatase-1 and on the tryptic digestion of fruit-fly phosphorylase a.

Original languageEnglish
Pages (from-to)657-659
Number of pages3
JournalInternational Journal of Biochemistry
Volume19
Issue number7
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Effect of ligands on Drosophila phosphorylase a as monitored by its enzymic inactivation'. Together they form a unique fingerprint.

  • Cite this