Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages

Cs Balázs, M. Szabó, P. Szerze, A. Leövey

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The ability of human polymorphonuclear granulocytes and alveolar macrophages from rats to ingest Saccharomyces cerevisiae was tested in vitro in the presence of various concentrations of emetine and libexine. Emetine 4.0 and 40.0 μg/ml caused an increase in the phagocytic index of polymorphonuclear granulocytes and alveolar macrophages. After oral administration of emetine the phagocytosis-enhancing effect was still apparent. Intracellular killing was not influenced by emetine or libexine.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume12
Issue number5
DOIs
Publication statusPublished - Sep 1 1977

Keywords

  • Emetine
  • alveolar macrophages
  • intracellular killing
  • libexine
  • phagocytosis
  • polymorphonuclear granulocytes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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