Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs

J. Papp, Piero Pollesello, A. Varró, A. Végh

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhythmias was compared in a model of acute regional myocardial ischemia and reperfusion. The left anterior descending coronary artery in dogs was occluded for 25 minutes, followed by reperfusion. The 2 drugs were administered in a hemodynamically equieffective dose (0.1 μmol/kg) 10 minutes before coronary occlusion. Levosimendan, but not milrinone, significantly attenuated the pronounced increase in the number of ventricular premature beats (-63%), tachycardia (-50%), fibrillation (-70%), and inhomogeneity of ventricular electrical activation. Levosimendan significantly improved the overall survival rate. Levosimendan has a more beneficial profile than milrinone regarding the development of ventricular arrhythmias during and after regional myocardial ischemia.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 2006

Fingerprint

Milrinone
Myocardial Reperfusion
Myocardial Ischemia
Cardiac Arrhythmias
Dogs
Phosphodiesterase Inhibitors
Heart Failure
Calcium
Ventricular Premature Complexes
Coronary Occlusion
Tachycardia
Reperfusion
Coronary Vessels
simendan
Pharmaceutical Preparations

Keywords

  • Levosimendan
  • Myocardial ischemia/reperfusion
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

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AU - Pollesello, Piero

AU - Varró, A.

AU - Végh, A.

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AB - Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhythmias was compared in a model of acute regional myocardial ischemia and reperfusion. The left anterior descending coronary artery in dogs was occluded for 25 minutes, followed by reperfusion. The 2 drugs were administered in a hemodynamically equieffective dose (0.1 μmol/kg) 10 minutes before coronary occlusion. Levosimendan, but not milrinone, significantly attenuated the pronounced increase in the number of ventricular premature beats (-63%), tachycardia (-50%), fibrillation (-70%), and inhomogeneity of ventricular electrical activation. Levosimendan significantly improved the overall survival rate. Levosimendan has a more beneficial profile than milrinone regarding the development of ventricular arrhythmias during and after regional myocardial ischemia.

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