Effect of levamisole and D-penicillamine on the activity of the rheumatoid arthritis, as well as on the parameters of the humoral and cellular immunity

L. Hodinka, K. Meretey, A. Falus, S. Bozsoky

Research output: Contribution to journalArticle

Abstract

10 patients with rheumatoid arthritis were treated for 6 months - according to an intermittent scheme - with levamisole. 10 corresponding controls with rheumtoid arthritis similarly for 6 months only with antiphlogistic drugs, and afterwards also with D-penicillinamine, similarly for 6 months. The characteristic features of the inflammatory activity, as well as the parameters of the humoral immunity (the immunoglobulin- and autoantitest levels, C3, circulatory immuno-complex levels), finally the parameters of the cellular immunity (skin reactivity, leukocyte migration inhibition and the monocyte phagocytosis) were registered. In contrast with the only antiphlogistic treatment, the inflammatory activity was reduced by both the levamisole and the D-penicillamine. No considerable change of the characteristics of the humoral immunity has been observed; on the other hand, the decreased cellular immunoreactivity of the patients was decreased by levamisol in greater degree, and by D-penicillinamine only in a lesser degree. During all three treatments the monocytes' phagocytefunction was variable.

Original languageEnglish
Pages (from-to)213-226
Number of pages14
JournalMagyar Reumatologia
Volume22
Issue number4
Publication statusPublished - Jan 1 1981

ASJC Scopus subject areas

  • Rheumatology

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