Effect of Lanthanum on the Release of Acetylcholine from the Myenteric Plexus and on Its Activation by Ouabain and Electrical Stimulation

Vladimir Doležal, Gyorgy T. Somogyi, Sandor Bernath, Stanislav Tuček, E. Sylvester Vizi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of lanthanum ions (La3+) on the release of acetylcholine (ACh) from longitudinal muscle strips of the guinea pig ileum with the myenteric plexus attached was investigated. After an exposure of the tissue to 2 mM LaCl3 for 18 min the rate of ACh release was increased approximately eightfold and the increased release lasted for more than 100 min. The augmented release of ACh was accompanied by enhanced synthesis. At the end of the experiments (102 min after LaCl3 had been removed), when the release of ACh was still more than six times higher than in controls, the content of ACh was the same in La3+‐treated and un treated tissues. Electrical field stimulation failed to cause a further increase in the release of ACh from La3+‐pretreated preparations whereas ouabain released considerable more ACh when compared to controls. It is concluded from this difference that electrical stimulation and ouabain release ACh from different pools.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalJournal of neurochemistry
Volume49
Issue number2
DOIs
Publication statusPublished - Aug 1987

Keywords

  • Acetylcholine release
  • Electrical stimulation
  • Lanthanum
  • Myenteric plexus
  • Ouabain

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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