Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

L-arginine has received much attention in numerous aspects of the regulation of vascular tone and haemostasis. L-arginine seems to be capable to bind to plasminogen, too. The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis. The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-argnine, along with augmentation of in vitro fibrinogenolysis have been documented. L-arginine may have a role in the modification of fibrinogenolysis, and this role should be considered if argnine is used as an element of some novel antithrombotic agents.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalThrombosis Research
Volume87
Issue number1
DOIs
Publication statusPublished - Jul 1 1997

Fingerprint

Fibrinolysin
Arginine
Fibrinolytic Agents
Plasminogen
Hemostasis
Blood Vessels
In Vitro Techniques

Keywords

  • Clot lysis
  • Fibrinogenolysis
  • Fibrinolysis
  • L-arginine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis. / Udvardy, M.; Posán, E.; Palatka, K.; Altorjay, I.; Hársfalvi, J.

In: Thrombosis Research, Vol. 87, No. 1, 01.07.1997, p. 75-82.

Research output: Contribution to journalArticle

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