Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis

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Abstract

L-arginine has received much attention in numerous aspects of the regulation of vascular tone and haemostasis. L-arginine seems to be capable to bind to plasminogen, too. The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis. The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-argnine, along with augmentation of in vitro fibrinogenolysis have been documented. L-arginine may have a role in the modification of fibrinogenolysis, and this role should be considered if argnine is used as an element of some novel antithrombotic agents.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalThrombosis research
Volume87
Issue number1
DOIs
Publication statusPublished - Jul 1 1997

Keywords

  • Clot lysis
  • Fibrinogenolysis
  • Fibrinolysis
  • L-arginine

ASJC Scopus subject areas

  • Hematology

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