Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design

Zs Sáska, J. Dredán, E. Balogh, O. Luhn, G. Shafir, I. Antal

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tablets containing paracetamol were prepared by wet granulation. The model drug, paracetamol (API) and the diluent, milled isomalt (IM) were applied in different ratios where the granulation liquid was kept constant in each sample. The purpose of the study was to investigate the effect of wet granulation with milled isomalt on the tabletting properties of poorly compressible paracetamol. The results of tabletting process and the tablet characteristics were evaluated with 32 type face-centered full factorial design. The API:IM ratio (X1) and compression force (X2) were selected as independent variables. The dependent variables were as follows: the parameters of the tabletting process - lubrication coefficient (R-value), relative elasticity, friction work - and characteristics of the dosage form such as tablet hardness, friability, disintegration time, tensile strength. The results indicated that milled isomalt has an advantageous effect on both the process of compression and the tablet characteristics - due to its binder properties. Furthermore an optimal composition of the API and the diluent is to be found according to the compression process and the dosage form.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalPowder Technology
Volume201
Issue number2
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Granulation
Acetaminophen
Compressibility
Application programming interfaces (API)
Tablets
Dosage Forms
Disintegration
Lubrication
Binders
Elasticity
Tensile strength
Hardness
Friction
Liquids
Chemical analysis
Palatinit
Pharmaceutical Preparations

Keywords

  • Binder
  • Compaction
  • Compressibility
  • Factorial design
  • Isomalt
  • Wet granulation

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design. / Sáska, Zs; Dredán, J.; Balogh, E.; Luhn, O.; Shafir, G.; Antal, I.

In: Powder Technology, Vol. 201, No. 2, 07.2010, p. 123-129.

Research output: Contribution to journalArticle

Sáska, Zs ; Dredán, J. ; Balogh, E. ; Luhn, O. ; Shafir, G. ; Antal, I. / Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design. In: Powder Technology. 2010 ; Vol. 201, No. 2. pp. 123-129.
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