Az ischaemia-reperfusio hatása az agyi vérkeringésre

Translated title of the contribution: Effect of ischemia-reperfusion on cerebral circulation

Research output: Contribution to journalArticle

Abstract

The aim of this review is to summarize the major changes in the cerebral circulation following ischemia. The vascular pathophysiology is multi-factorial therefore we focus on the changes in the arterial and microcirculatory system. We characterize the endothelial components of vasodilation and vasoconstriction and we describe the basic mechanisms of hyper- and depolarization of vascular smooth muscle. We focus on the role of endothelium-derived nitric oxide (NO) and prostacyclin (PGI2) in vasodilation. We summarize the most important properties of K+-channels found in vascular smooth muscle. We underline that altered balance between the dilator and constrictor substances together with selective impairment of K+-channel function lead to increased vasotonus. Changes in blood viscosity also reduce brain perfusion. Causal factors include overproduction and action of reactive oxygen species. We discuss the most important strategies of the treatment of post-ischemic hypoperfusion.

Original languageHungarian
Pages (from-to)28-36
Number of pages9
JournalOrvoskepzes
Volume77
Issue number1
Publication statusPublished - 2002

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Cerebrovascular Circulation
Epoprostenol
Vascular Smooth Muscle
Vasodilation
Reperfusion
Ischemia
Blood Viscosity
Vasoconstriction
Blood Vessels
Reactive Oxygen Species
Nitric Oxide
Perfusion
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az ischaemia-reperfusio hatása az agyi vérkeringésre. / Bari, F.

In: Orvoskepzes, Vol. 77, No. 1, 2002, p. 28-36.

Research output: Contribution to journalArticle

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