Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging

Akos Varga-Szemes, Rob J. van der Geest, U. Joseph Schoepf, Bruce S. Spottiswoode, Carlo N. de Cecco, Giuseppe Muscogiuri, Julian L. Wichmann, Stefanie Mangold, Stephen R. Fuller, Pal Maurovich-Horvat, B. Merkely, Sheldon E. Litwin, Rozemarijn Vliegenthart, Pal Suranyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI• Synthetic IR imaging can simulate the effect of TI on LGE quantification• Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms• Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI• Synthetic IR imaging has further advantages in reducing operator dependence

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalEuropean Radiology
DOIs
Publication statusAccepted/In press - Jan 3 2017

Fingerprint

Gadolinium
Myocardial Infarction
Image Enhancement
Analysis of Variance

Keywords

  • Cardiovascular magnetic resonance
  • Late gadolinium enhancement
  • Myocardial infarct
  • Synthetic inversion recovery
  • T1 mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Varga-Szemes, A., van der Geest, R. J., Schoepf, U. J., Spottiswoode, B. S., de Cecco, C. N., Muscogiuri, G., ... Suranyi, P. (Accepted/In press). Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging. European Radiology, 1-9. https://doi.org/10.1007/s00330-016-4665-z

Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging. / Varga-Szemes, Akos; van der Geest, Rob J.; Schoepf, U. Joseph; Spottiswoode, Bruce S.; de Cecco, Carlo N.; Muscogiuri, Giuseppe; Wichmann, Julian L.; Mangold, Stefanie; Fuller, Stephen R.; Maurovich-Horvat, Pal; Merkely, B.; Litwin, Sheldon E.; Vliegenthart, Rozemarijn; Suranyi, Pal.

In: European Radiology, 03.01.2017, p. 1-9.

Research output: Contribution to journalArticle

Varga-Szemes, A, van der Geest, RJ, Schoepf, UJ, Spottiswoode, BS, de Cecco, CN, Muscogiuri, G, Wichmann, JL, Mangold, S, Fuller, SR, Maurovich-Horvat, P, Merkely, B, Litwin, SE, Vliegenthart, R & Suranyi, P 2017, 'Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging', European Radiology, pp. 1-9. https://doi.org/10.1007/s00330-016-4665-z
Varga-Szemes, Akos ; van der Geest, Rob J. ; Schoepf, U. Joseph ; Spottiswoode, Bruce S. ; de Cecco, Carlo N. ; Muscogiuri, Giuseppe ; Wichmann, Julian L. ; Mangold, Stefanie ; Fuller, Stephen R. ; Maurovich-Horvat, Pal ; Merkely, B. ; Litwin, Sheldon E. ; Vliegenthart, Rozemarijn ; Suranyi, Pal. / Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging. In: European Radiology. 2017 ; pp. 1-9.
@article{8192631b3d954a8f8923ec4fb69a3000,
title = "Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging",
abstract = "Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI• Synthetic IR imaging can simulate the effect of TI on LGE quantification• Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms• Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI• Synthetic IR imaging has further advantages in reducing operator dependence",
keywords = "Cardiovascular magnetic resonance, Late gadolinium enhancement, Myocardial infarct, Synthetic inversion recovery, T1 mapping",
author = "Akos Varga-Szemes and {van der Geest}, {Rob J.} and Schoepf, {U. Joseph} and Spottiswoode, {Bruce S.} and {de Cecco}, {Carlo N.} and Giuseppe Muscogiuri and Wichmann, {Julian L.} and Stefanie Mangold and Fuller, {Stephen R.} and Pal Maurovich-Horvat and B. Merkely and Litwin, {Sheldon E.} and Rozemarijn Vliegenthart and Pal Suranyi",
year = "2017",
month = "1",
day = "3",
doi = "10.1007/s00330-016-4665-z",
language = "English",
pages = "1--9",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging

AU - Varga-Szemes, Akos

AU - van der Geest, Rob J.

AU - Schoepf, U. Joseph

AU - Spottiswoode, Bruce S.

AU - de Cecco, Carlo N.

AU - Muscogiuri, Giuseppe

AU - Wichmann, Julian L.

AU - Mangold, Stefanie

AU - Fuller, Stephen R.

AU - Maurovich-Horvat, Pal

AU - Merkely, B.

AU - Litwin, Sheldon E.

AU - Vliegenthart, Rozemarijn

AU - Suranyi, Pal

PY - 2017/1/3

Y1 - 2017/1/3

N2 - Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI• Synthetic IR imaging can simulate the effect of TI on LGE quantification• Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms• Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI• Synthetic IR imaging has further advantages in reducing operator dependence

AB - Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI• Synthetic IR imaging can simulate the effect of TI on LGE quantification• Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms• Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI• Synthetic IR imaging has further advantages in reducing operator dependence

KW - Cardiovascular magnetic resonance

KW - Late gadolinium enhancement

KW - Myocardial infarct

KW - Synthetic inversion recovery

KW - T1 mapping

UR - http://www.scopus.com/inward/record.url?scp=85008219306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008219306&partnerID=8YFLogxK

U2 - 10.1007/s00330-016-4665-z

DO - 10.1007/s00330-016-4665-z

M3 - Article

SP - 1

EP - 9

JO - European Radiology

JF - European Radiology

SN - 0938-7994

ER -