Effect of intraventricular glutamate on ACTH release

G. B. Makara, E. Stark

Research output: Contribution to journalArticle

47 Citations (Scopus)


Sodium glutamate infused into the 3rd ventricle is a potent stimulus of ACTH release, as shown by the rise in plasma corticosterone levels. Glutamate failed to consistently increase the plasma corticosterone level in rats with deafferentation of the medial basal hypothalamus (MBH). We suggest that intraventricular glutamate interferes with central nervous function outside the MBH and stimulates ACTH release via afferent neural pathways.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
Issue number2
Publication statusPublished - Jan 1 1975

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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