Effect of intravenous cimetidine, ranitidine and pentagastrin and intragastric prostaglandin E1 treatments on gastric transmucosal potential difference in the rat

I. Racz, D. Szombath, G. Szekely

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Abstract

Effects of intravenous cimetidine, ranitidine and intragastric prostaglandin E1 (alprostadil) treatments on the transmucosal potential difference (PD) of the stomach were compared. It was also investigated whether the above-mentioned drugs influenced the decrease of PD which followed both intragastric administration of 30% alcohnol or Ca++ solution in 5 Mm final concentration and intravenous administration of pentagastrin. Both cimetidine and ranitidine treatments led to significant (p < 0.05) increase of PD, the effect of ranitidine was dose-dependent. Prostaglandin E1 in a dose of 40 μg/kg led to significant decrease of PD (< 0.05). Both intragastric administration of prostaglandin E1 in a dose of 40 μg/kg and intravenous administration of ranitidine in a dose of 10 mg/kg significantly diminish the effect of Ca++ and alcohol to decrease PD. Neither prostaglandin E1, nor ranitidine pretreatment had any effect on the rapid and highly significant (p < 0.01) decrease of PD following i.v. pentagastrin administration. It is hypothesized that transmucosal PD of the stomach provides information not only on the actual condition of the mucosal barrier but on the electrophysiology of gastric secretion as well.

Original languageEnglish
Pages (from-to)241-252
Number of pages12
JournalActa physiologica Hungarica
Volume79
Issue number3
Publication statusPublished - Dec 1 1992

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Keywords

  • Ca
  • PGE
  • alcohol
  • cimetidine
  • gastric
  • pentagastrin
  • ranitidine
  • transmucosal potential difference

ASJC Scopus subject areas

  • Physiology (medical)

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