To study its glycemic effect and to evaluate alpha cell function, L-alanine was administered intravenously (0.15 g/kg b.w.) to ketotic diabetic children. Their preinfusion condition was characterized by hyperglycemia, elevated alanine, glucagon and growth hormone levels. Alanine failed to cause a further increase in the plasma glucagon level and had no glycemic effect, but induced a consistent rise in plasma growth hormone. It is concluded that, in contrast with adult diabetics, alanine had no glycemic effect and was not a potent alpha-cell secretagogue in ketotic diabetic children. The demonstrated growth-hormone provoking effect suggests that endogenous hyperalaninemia may contribute to ketosis via the anti-insulin effect of growth hormone.
|Number of pages||6|
|Journal||Acta paediatrica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1982|
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