Effect of intravenous alanine on blood glucose, glucagon and growth hormone levels in diabetic children

G. Soltesz, D. Molnar, J. Mestyan

Research output: Contribution to journalArticle

Abstract

To study its glycemic effect and to evaluate alpha cell function, L-alanine was administered intravenously (0.15 g/kg b.w.) to ketotic diabetic children. Their preinfusion condition was characterized by hyperglycemia, elevated alanine, glucagon and growth hormone levels. Alanine failed to cause a further increase in the plasma glucagon level and had no glycemic effect, but induced a consistent rise in plasma growth hormone. It is concluded that, in contrast with adult diabetics, alanine had no glycemic effect and was not a potent alpha-cell secretagogue in ketotic diabetic children. The demonstrated growth-hormone provoking effect suggests that endogenous hyperalaninemia may contribute to ketosis via the anti-insulin effect of growth hormone.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalActa paediatrica Academiae Scientiarum Hungaricae
Volume23
Issue number2
Publication statusPublished - Dec 1 1982

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ASJC Scopus subject areas

  • Medicine(all)

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