Effect of intratesticular administration of TRH or anti-TRH antiserum on function of rat testis

Ida Gerendai, Péter Sziebert, Tamás Görcs, Zsolt Csaba, Valér Csernus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of intratesticular administration of thyrotropin-releasing hormone (TRH) and anti-TRH antiserum on steroidogenesis was studied in immature and adult rats. In 9-day-old animals local administration of the neuropeptide resulted in an increase in basal testosterone secretion in vitro. Similar treatment of 15-day-old rats suppressed hCG-stimulated testosterone secretion with no change in basal testosterone production. In both immature groups the treatment did not affect serum testosterone concentration. By contrast, in adults TRH decreased serum testosterone level, but did not influence basal and hCG-stimulated testosterone secretion. Both in immature and adult rats, the changes in steroidogenesis were evident 1 hour posttreatment. Five days after the administration of anti-TRH antiserum into the remaining testis of immature rats subjected to hemicastration just prior to the antiserum treatment, the alterations in steroidogenesis were opposite to those detected after treatment with TRH. In 9-day-old rats the antiserum suppressed steroidogenesis, while in 15-day-old animals it stimulated testosterone secretion. The results suggest that testicular TRH might exert a local action on testicular steroidogenesis, and the effect is age-dependent. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)269-281
Number of pages13
JournalLife Sciences
Volume67
Issue number3
DOIs
Publication statusPublished - Jun 9 2000

Keywords

  • Age- dependent effect
  • Anti-TRH antiserum
  • Local control
  • Neuropeptide
  • Steroidogenesis
  • TRH

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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