Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre.

Translated title of the contribution: Effect of intra-arterial chemotherapy of head and neck tumors on cerebral blood circulation

L. Pávics, Z. Tóth Bagi, L. Almási, E. Ambrus, G. Szabó, L. Csernay

Research output: Contribution to journalArticle

Abstract

A combination of Cisplatin and Epirubicin was administered through the external carotid artery system according to a standard protocol as preoperative or palliative therapy in 14 oral cancer patients. With the aim of clarifying the subacute side-effects of this chemotherapy on the intracerebral circulation, rCBF SPECT investigations with 99mTc-HMPAO were performed before and after the cytostatic treatment. The interval between SPECT studies was 24 (SD +/- 12) days. In concordance with the neurological condition, visual assessment of the rCBF SPECT reconstructed transversal slices revealed no perfusion abnormalities and no changes on the follow-up. No significant changes were found in the side activity ratios in 22 regions of each hemisphere (unpaired t-test) in the whole group of patients. It was concluded that within the investigated time interval this highly effective combination of cytostatics administered perfectly through the external carotid artery system causes no serious disturbances in the cerebral circulation in oral cancer cases.

Original languageHungarian
Pages (from-to)1041-1042, 1047
JournalOrvosi Hetilap
Volume133
Issue number17
Publication statusPublished - Apr 26 1992

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Cerebrovascular Circulation
Blood Circulation
Single-Photon Emission-Computed Tomography
External Carotid Artery
Neck
Mouth Neoplasms
Head
Cytostatic Agents
Drug Therapy
Technetium Tc 99m Exametazime
Neoplasms
Epirubicin
Palliative Care
Cisplatin
Perfusion
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pávics, L., Tóth Bagi, Z., Almási, L., Ambrus, E., Szabó, G., & Csernay, L. (1992). Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre. Orvosi Hetilap, 133(17), 1041-1042, 1047.

Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre. / Pávics, L.; Tóth Bagi, Z.; Almási, L.; Ambrus, E.; Szabó, G.; Csernay, L.

In: Orvosi Hetilap, Vol. 133, No. 17, 26.04.1992, p. 1041-1042, 1047.

Research output: Contribution to journalArticle

Pávics, L, Tóth Bagi, Z, Almási, L, Ambrus, E, Szabó, G & Csernay, L 1992, 'Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre.', Orvosi Hetilap, vol. 133, no. 17, pp. 1041-1042, 1047.
Pávics L, Tóth Bagi Z, Almási L, Ambrus E, Szabó G, Csernay L. Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre. Orvosi Hetilap. 1992 Apr 26;133(17):1041-1042, 1047.
Pávics, L. ; Tóth Bagi, Z. ; Almási, L. ; Ambrus, E. ; Szabó, G. ; Csernay, L. / Fej és nyaki tumorok intraarteriális chemotherapiájának hatása az agyi keringésre. In: Orvosi Hetilap. 1992 ; Vol. 133, No. 17. pp. 1041-1042, 1047.
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