Effect of interleukin-1β on plasma ACTH, β-endorphin, and corticosterone levels in infant and prepubertal rats

I. Barna, Zsuzsanna Ács, Gyula Bugovics, James I. Koenig

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

IL-1/β is known to enhance ACTH release from the anterior pituitary in the adult rat, mainly by simulating the hypothalamic ACTH-releasing hormone (CRH) release, but it seems to have a direct effect on the pituitary and on the adrenal hormone secretion, too. The effect of IL-1β on the β-endorphin (βE) secretion from the intermediate lobe is less well studied. There is very little information on the effect of IL-1/β on the hypothalamic-pituitary-adrenal axis (HPAA) in the postnatal rat, which is a special period, because the reactivity of the HPAA is blunted. The effect of IL-1β in this period seemed to be of special interest, because neither the immune nor the endocrine system is fully developed. In the present study we tested the 30- and 120-min effect of intraperitoneally administered 0.5 and 100 ng/g body weight IL-1β on the plasma immunoreactive (ir) ACTH, βE, and corticosterone (CS) levels in the 10-d-old (infant) and 30-d-old (prepubertal) rat. Generally, the ir-ACTH, ir-βE, and ir-CS levels were significantly higher in prepubertal than in infant rats. Hormone levels were more enhanced by the higher dose of IL-1β, and changes were more pronounced at 120 min than at 30 min. The relative increase of ir-ACTH and ir-βE was smaller in the infant than in the prepubertal rat. In contrast, the relative increase of ir-CS was more pronounced in the infant rat. Changes in plasma ir-βE and ir-ACTH levels were not parallel, suggesting different responsiveness of the anterior pituitary corticotrophs and intermediate pituitary melanotrophs to IL-1β stimulation. The age-related peculiarities in response to IL-1β could be due to a different secretory capacity and/or different kinetics of the HPAA in the infant (10-d-old) and prepubertal (30-d-old) rat. There could be a change in sensitivity of different components of the HPAA (hypothalamus, pituitary, adrenal) to IL-1β during the postnatal development.

Original languageEnglish
Pages (from-to)714-719
Number of pages6
JournalPediatric Research
Volume37
Issue number6
Publication statusPublished - 1995

Fingerprint

Endorphins
Corticosterone
Interleukin-1
Adrenocorticotropic Hormone
Melanotrophs
Corticotrophs
Hormones
Pituitary Hormone-Releasing Hormones
Endocrine System
Corticotropin-Releasing Hormone
Hypothalamus
Body Weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of interleukin-1β on plasma ACTH, β-endorphin, and corticosterone levels in infant and prepubertal rats. / Barna, I.; Ács, Zsuzsanna; Bugovics, Gyula; Koenig, James I.

In: Pediatric Research, Vol. 37, No. 6, 1995, p. 714-719.

Research output: Contribution to journalArticle

Barna, I. ; Ács, Zsuzsanna ; Bugovics, Gyula ; Koenig, James I. / Effect of interleukin-1β on plasma ACTH, β-endorphin, and corticosterone levels in infant and prepubertal rats. In: Pediatric Research. 1995 ; Vol. 37, No. 6. pp. 714-719.
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