Effect of insulin on the incorporation of3H-inositol into the inositol phospholipids (PI, PIP, PIP2) and Glycosyl-phoshatidylinositols (GPIs) of Tetrahymena pyriformis

P. Kovács, G. Csaba

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The unicellular tetrahymena contains inositol phospholipids (PI, PIP, PIP2) and GPIs. Treatment with 10-5M insulin decreases the total3H-inositol incorporation and incorporation into PI. 24 h after 10-6M insulin treatment there is an elevation of these parameters. Second treatment with 10-6M insulin doubles and 10-5M decreases these levels. This means that the effect on phosphoinositide turnover by insulin in Tetrahymena is rather concentration dependent. Inositol incorporation into GPIs is also influenced by insulin.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalBioscience Reports
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 1 1994

Keywords

  • GPIs
  • Tetrahymena
  • hormonal imprinting
  • inositol phospholipids
  • insulin
  • second messengers

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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