Effect of insulin and glucagon on the uptake of carnitine by perfused rat liver

Gyula Kispal, Bela Melegh, Attila Sandor

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The possible direct effects of insulin and glucagon on carnitine uptake by perfused rat liver were studied with l-[3H]carnitine of an initial concentration of 50 μM in the perfusate. Insulin (10 nM) did not significantly affect the uptake by livers from fed animals. However, insulin could reverse the stimulated transport by livers from 24-h fasted animals, reducing the uptake rate from 852 ± 54.1 to 480 ± 39.9 (mean ± S.E.), P < 0.01 (rates are expressed as nmol per h per 100 g body wt). Glucagon (50 nM) stimulated the uptake rate when livers were either from fed (551 ± 40.1 vs. 915 ± 55.3, P < 0.01) or from fasted animals (852 ± 54.1 vs. 1142 ± 88.1, P < 0.02). Based on these and earlier observations, we propose that the carnitine concentration in rat liver is controlled by insulin and glucagon via cellular transport processes.

Original languageEnglish
Pages (from-to)226-228
Number of pages3
JournalBBA - Molecular Cell Research
Volume929
Issue number2
DOIs
Publication statusPublished - Jul 6 1987

Keywords

  • (Rat liver)
  • Carnitine transport
  • Glucagon
  • Insulin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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