Effect of indomethacin treatment on plasma renin activity and plasma aldosterone concentration in late pregnancy

M. Nemeth, I. Tenyi, E. Sulyok

Research output: Contribution to journalArticle

Abstract

In the present study we made an attempt to obtain information as to whether the increased endogenous PG production during pregnancy might play a role in producing hyperactivity of the renin-angiotensin-aldosterone system (RAAS) in pregnant women. Two groups, each including 8 pregnant women with Bishop score of 8 or more, were selected for the study. One group was treated with indomethacin under the protocol of Zuckerman et al. in a dose of 100 mg/day for 1-3 days in order to prevent premature delivery or control uterine activity at term, whereas the other group received placebo. Indomethacin treatment resulted in a decrease of both PRA and PA. At the same time an apparent, but statistically non significant rise of PRA and PA was found in the non-treated group. There was no discernible difference either in plasma Na and K concentration or in urinary Na and K excretion between the treated and control group.

Original languageEnglish
Pages (from-to)579
Number of pages1
JournalIRCS Medical Science
Volume7
Issue number11
Publication statusPublished - 1979

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Aldosterone
Renin
Indomethacin
Pregnant Women
Thermodynamic properties
Plasmas
Pregnancy
Angiotensins
Renin-Angiotensin System
Placebos
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effect of indomethacin treatment on plasma renin activity and plasma aldosterone concentration in late pregnancy. / Nemeth, M.; Tenyi, I.; Sulyok, E.

In: IRCS Medical Science, Vol. 7, No. 11, 1979, p. 579.

Research output: Contribution to journalArticle

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