Effect of indomethacin on the adrenal response to frusemide in the rat

A. Spat, S. Jozan, K. Gaal, T. Mozes

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2 Citations (Scopus)

Abstract

The effect of acute diuretic treatment on peripheral aldosterone concentration or aldosterone secretion rate in the rat has not yet been reported. In the present experiments frusemide evoked a sixfold increase in mean peripheral aldosterone concentration within 2 h followed by a gradual fall lasting for at least 6h. Thus acute fluid depletion evoked hyperaldosteronism in the rat as effectively as in other species. The simultaneous increase of corticosterone values indicates a possible contribution of corticotrophin to this response albeit the mean corticosterone level was below 200 ng/ml. Pretreatment with indomethacin abolished the increase in peripheral aldosterone concentration 2 h after administration of frusemide. One hour later the effect of indomethacin was less pronounced, although a significant negative interaction (P<0.025) between frusemide and indomethacin was revealed even at this time by a four-sample modification of the d-test of Behrens & Fisher. No significant changes were observed in plasma Na+ or K+ levels. Both basal and frusemide-induced sodium and urine excretion rates were reduced by indomethacin; K+ excretion rate was unaffected.

Original languageEnglish
Pages (from-to)401-402
Number of pages2
JournalJournal of Endocrinology
Volume73
Issue number2
DOIs
Publication statusPublished - Jan 1 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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