Effect of indomethacin on the adrenal response to frusemide in the rat

A. Spät, S. Jozan, K. Gaal, T. Mozes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of acute diuretic treatment on peripheral aldosterone concentration or aldosterone secretion rate in the rat has not yet been reported. In the present experiments frusemide evoked a sixfold increase in mean peripheral aldosterone concentration within 2 h followed by a gradual fall lasting for at least 6h. Thus acute fluid depletion evoked hyperaldosteronism in the rat as effectively as in other species. The simultaneous increase of corticosterone values indicates a possible contribution of corticotrophin to this response albeit the mean corticosterone level was below 200 ng/ml. Pretreatment with indomethacin abolished the increase in peripheral aldosterone concentration 2 h after administration of frusemide. One hour later the effect of indomethacin was less pronounced, although a significant negative interaction (P+ or K+ levels. Both basal and frusemide-induced sodium and urine excretion rates were reduced by indomethacin; K+ excretion rate was unaffected.

Original languageEnglish
Pages (from-to)401-402
Number of pages2
JournalJournal of Endocrinology
Volume73
Issue number2
Publication statusPublished - 1977

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Furosemide
Aldosterone
Indomethacin
Corticosterone
Hyperaldosteronism
Diuretics
Adrenocorticotropic Hormone
Sodium
Urine

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of indomethacin on the adrenal response to frusemide in the rat. / Spät, A.; Jozan, S.; Gaal, K.; Mozes, T.

In: Journal of Endocrinology, Vol. 73, No. 2, 1977, p. 401-402.

Research output: Contribution to journalArticle

Spät, A, Jozan, S, Gaal, K & Mozes, T 1977, 'Effect of indomethacin on the adrenal response to frusemide in the rat', Journal of Endocrinology, vol. 73, no. 2, pp. 401-402.
Spät, A. ; Jozan, S. ; Gaal, K. ; Mozes, T. / Effect of indomethacin on the adrenal response to frusemide in the rat. In: Journal of Endocrinology. 1977 ; Vol. 73, No. 2. pp. 401-402.
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