The effects of in vivo and in vitro treatment with human dialyzable leukocyte extracts (DLE) on natural killer (NK) cell activity were studied in 12 patients with malignancies in an allogenic test system using K-562 target cells. A marked increase in NK cell activity was observed in 7 patients with originally low cytotoxic capacity, while originally normal NK cell activity of other tumor patients and of healthy subjects was not significantly influenced by DLE treatment. The observed stimulation of NK cell activity by DLE may be a possible mechanism of its therapeutic effects.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine