The number of circulating lymphocytes and the number of B and T lymphocytes were estimated in blood samples of 38 patients with biopsy-verified chronic active hepatitis before and after combined immunosuppressive therapy. In chronic active hepatitis, the numnber of total lymphocytes and T cells decreased; the B lymphocytes showed no evaluable change. Immunosuppressive therapy led to a further decrease of total lymphocytes and of T and B cells. The decrease of IgG- and IgM-bearing lymphocytes was parallel to the reduction of corresponding immunoglobulin concentration. These data indicate that immunosuppressive therapy with steroids and azathioprine further affects the immune reaction in chronic active hepatitis.
|Number of pages||9|
|Journal||Acta Medica Academiae Scientiarum Hungaricae|
|Publication status||Published - 1981|
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