Effect of immunosuppressive therapy on lymphocyte populations in patients with chronic active hepatitis

J. Fehér, T. Pozsonyi, L. Jakab, G. Filipp

Research output: Contribution to journalArticle

Abstract

The number of circulating lymphocytes and the number of B and T lymphocytes were estimated in blood samples of 38 patients with biopsy-verified chronic active hepatitis before and after combined immunosuppressive therapy. In chronic active hepatitis, the numnber of total lymphocytes and T cells decreased; the B lymphocytes showed no evaluable change. Immunosuppressive therapy led to a further decrease of total lymphocytes and of T and B cells. The decrease of IgG- and IgM-bearing lymphocytes was parallel to the reduction of corresponding immunoglobulin concentration. These data indicate that immunosuppressive therapy with steroids and azathioprine further affects the immune reaction in chronic active hepatitis.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalActa Medica Academiae Scientiarum Hungaricae
Volume38
Issue number1
Publication statusPublished - 1981

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Chronic Hepatitis
Immunosuppressive Agents
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Population
Azathioprine
Lymphocyte Count
Immunoglobulin M
Immunoglobulins
Therapeutics
Immunoglobulin G
Steroids
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of immunosuppressive therapy on lymphocyte populations in patients with chronic active hepatitis. / Fehér, J.; Pozsonyi, T.; Jakab, L.; Filipp, G.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 38, No. 1, 1981, p. 39-47.

Research output: Contribution to journalArticle

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