Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

Arpad Tosaki, Matyas Koltai, Monique Paubert-Braquet

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Isolated hearts excised from normotensive (NT) and spontaneously hypertensive (SH) rats subjected to transient normothermic global ischemia were used to study the effect of chronic treatment with iloprost on reperfusion-induced arrhythmias and myocardiat ion shifts. After 30 min of ischemia, iloprost given s.c. in doses of 10, 50, 100 and 200 μg/kg per day for 14 days reduced the incidence of reperfusion-induced ventricular fibrillation (VF) in isolated hearts from the control value of 91 to 83. 75, 50 (P < 0.05) and 25% (P < 0.01) respectively, in NT rats. In the SH groups, the incidence of VF was also reduced from 100 to 75, 58, 33 (P < 0.01) and 17% (P < 0.001), respectively, with 10, 50,100 and 200 (μg/kg per day of iloprost. A similar reduction was observed in the incidence of reperfusion-induced ventricular tachycardia (VT). Ischemia and reperfusion caused significant changes in myocardial ion contents, i.e. an increase in Na+ and Ca2+ and a decrease in K+ and Mg2+ concentrations. The myocardial water content was also increased in parallel to the Na+ gain. The effect of iloprost given s.c. in doses of 50 and 200 μg/kg per day for 14 days was also measured on myocardial ion contents after 15- or 30-min ischemia and 30-min ischemia plus 10-min reperfusion. The higher iloprost dose significantly reduced the myocardial Na+ Ca2+ and water gains and the loss of K+ induced by ischemia and reperfusion in the NT and SH groups, while the decrease in Mg2+ content was alleviated only in SH rats. The results suggest that long-term iloprost treatment reduces the incidence of reperfusion-induced VF and VT by preventing Na+, Ca2+ and water accumulation as well as K+ and Mg2+ loss from myocardial tissue.

Original languageEnglish
Pages (from-to)69-81
Number of pages13
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - Nov 20 1990



  • Arrhythmias
  • Heart (rat)
  • Myocardial K, Myocardial Ca
  • Myocardial Mg
  • Myocardial Na
  • Reperfusion

ASJC Scopus subject areas

  • Pharmacology

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