Effect of ICV administered CRF-antiserum on the neurohypophyseal hormone levels in rat brain and plasma

M. Vecsernyés, F. Laczi, J. Julesz, G. Szabo, Z. Sarnyai, E. Biro, J. Gardi, G. Telegdy

Research output: Contribution to journalArticle

Abstract

The present experiments were scheduled to study the role of the endogenous brain CRF system in the central and peripheral secretion of the neurohypophyseal hormones. CRF antiserum (1:10 dilution, 2 μl) was given into the lateral ventricle of the brain of Wistar male rats. The animals were decapitated 24 h later and arginine-vasopressin (AVP), oxytocin (OXT) levels of the hippocampus, septum, amygdala, hypothalamus and blood plasma were measured by RIA aud plasma corticosterone (B) by fluorimetry. The AVP content of the septum was increased and OXT of the amygdala decreased by the treatment, while the peripheral hormone secretions did not change. These results suggest that the central CRF-ergic system may be involved in the activities of the AVP- and OXT-ergic systems of certain brain regions, but it does not alter the basal secretion of these hormones and B into the peripheral blood.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalEndocrine Regulations
Volume29
Issue number1
Publication statusPublished - 1995

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Posterior Pituitary Hormones
Arginine Vasopressin
Vasotocin
Immune Sera
Amygdala
Brain
Hormones
Fluorometry
Lateral Ventricles
Oxytocin
Corticosterone
Hypothalamus
Wistar Rats
Hippocampus

Keywords

  • arginine-8-vasopressin
  • brain
  • CRF
  • oxytocin
  • plasma

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of ICV administered CRF-antiserum on the neurohypophyseal hormone levels in rat brain and plasma. / Vecsernyés, M.; Laczi, F.; Julesz, J.; Szabo, G.; Sarnyai, Z.; Biro, E.; Gardi, J.; Telegdy, G.

In: Endocrine Regulations, Vol. 29, No. 1, 1995, p. 57-61.

Research output: Contribution to journalArticle

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