Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius

Ildikó Bódi, Balázs Felföldi, Krisztina Minkó, Zsófia Benyeda, N. Nagy, A. Kiss, Vilmos Palya, Imre Oláh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the chicken bursa of Fabricius (BF), the interfollicular epithelium (IFE) consists of cylindrical- and cuboidal-shaped cells. Among the cylindrical-shaped epithelial cells, mucus-producing and caveolin-1 (Cav-1)-expressing cells can be distinguished. Occasionally, the cuboidal-shaped cells also express Cav-1, which suggests that they are precursors of both mucus-producing and Cav-1-expressing cells. Very virulent infectious bursal disease virus (IBDV) impedes the differentiation of Cav-1-expressing cells and shifts the differentiation of cuboidal cells towards mucus-producing cells. In control birds exclusively, the IFE surface shows a mucous membrane, but after IBDV infection, the surfaces of both IFE and FAE are also covered by a mucous membrane. After IBDV infection, the cells of FAE also produce mucus, providing evidence for cell transformation. In late postinfection (pi; 28 d pi), the Cav-1 expression returned in the IFE cells, whereas the follicle (the primary lymphoid organ) underwent atrophy. The appearance of the renewed Cav-1-positive cells is similar to that of the normal basal cell, but they randomly locate in different levels of IFE, suggesting the loss of epithelial polarity. Between days 2 and 7 pi, the Cav-1 expression in the endothelial cells of the cortico-medullary capillary web is variable, which may explain the hemorrhage in several infected birds. The IBDV infection stops the Cav-1 expression and subsequently the cholesterol efflux into the bursal lumen. In the infected birds, the high cholesterol level may further worsen the clinical syndrome of IBDV.

Original languageEnglish
Pages (from-to)3464-3470
Number of pages7
JournalPoultry science
Volume98
Issue number9
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Infectious bursal disease virus
bursa of Fabricius
epithelium
chickens
infection
mucus
cells
mucosa
cholesterol
bird control
birds
atrophy
cell differentiation
endothelial cells
hemorrhage
epithelial cells

Keywords

  • caveolin-1
  • IBDV infection
  • interfollicular epithelium
  • mucous membrane
  • transformation of FAE and medullary reticular epithelial cell

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius. / Bódi, Ildikó; Felföldi, Balázs; Minkó, Krisztina; Benyeda, Zsófia; Nagy, N.; Kiss, A.; Palya, Vilmos; Oláh, Imre.

In: Poultry science, Vol. 98, No. 9, 01.09.2019, p. 3464-3470.

Research output: Contribution to journalArticle

Bódi, I, Felföldi, B, Minkó, K, Benyeda, Z, Nagy, N, Kiss, A, Palya, V & Oláh, I 2019, 'Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius', Poultry science, vol. 98, no. 9, pp. 3464-3470. https://doi.org/10.3382/ps/pey512
Bódi, Ildikó ; Felföldi, Balázs ; Minkó, Krisztina ; Benyeda, Zsófia ; Nagy, N. ; Kiss, A. ; Palya, Vilmos ; Oláh, Imre. / Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius. In: Poultry science. 2019 ; Vol. 98, No. 9. pp. 3464-3470.
@article{a262b2e02e4b4d0fa89de42aab45e877,
title = "Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius",
abstract = "In the chicken bursa of Fabricius (BF), the interfollicular epithelium (IFE) consists of cylindrical- and cuboidal-shaped cells. Among the cylindrical-shaped epithelial cells, mucus-producing and caveolin-1 (Cav-1)-expressing cells can be distinguished. Occasionally, the cuboidal-shaped cells also express Cav-1, which suggests that they are precursors of both mucus-producing and Cav-1-expressing cells. Very virulent infectious bursal disease virus (IBDV) impedes the differentiation of Cav-1-expressing cells and shifts the differentiation of cuboidal cells towards mucus-producing cells. In control birds exclusively, the IFE surface shows a mucous membrane, but after IBDV infection, the surfaces of both IFE and FAE are also covered by a mucous membrane. After IBDV infection, the cells of FAE also produce mucus, providing evidence for cell transformation. In late postinfection (pi; 28 d pi), the Cav-1 expression returned in the IFE cells, whereas the follicle (the primary lymphoid organ) underwent atrophy. The appearance of the renewed Cav-1-positive cells is similar to that of the normal basal cell, but they randomly locate in different levels of IFE, suggesting the loss of epithelial polarity. Between days 2 and 7 pi, the Cav-1 expression in the endothelial cells of the cortico-medullary capillary web is variable, which may explain the hemorrhage in several infected birds. The IBDV infection stops the Cav-1 expression and subsequently the cholesterol efflux into the bursal lumen. In the infected birds, the high cholesterol level may further worsen the clinical syndrome of IBDV.",
keywords = "caveolin-1, IBDV infection, interfollicular epithelium, mucous membrane, transformation of FAE and medullary reticular epithelial cell",
author = "Ildik{\'o} B{\'o}di and Bal{\'a}zs Felf{\"o}ldi and Krisztina Mink{\'o} and Zs{\'o}fia Benyeda and N. Nagy and A. Kiss and Vilmos Palya and Imre Ol{\'a}h",
year = "2019",
month = "9",
day = "1",
doi = "10.3382/ps/pey512",
language = "English",
volume = "98",
pages = "3464--3470",
journal = "Poultry Science",
issn = "0032-5791",
publisher = "Poultry Science Association",
number = "9",

}

TY - JOUR

T1 - Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius

AU - Bódi, Ildikó

AU - Felföldi, Balázs

AU - Minkó, Krisztina

AU - Benyeda, Zsófia

AU - Nagy, N.

AU - Kiss, A.

AU - Palya, Vilmos

AU - Oláh, Imre

PY - 2019/9/1

Y1 - 2019/9/1

N2 - In the chicken bursa of Fabricius (BF), the interfollicular epithelium (IFE) consists of cylindrical- and cuboidal-shaped cells. Among the cylindrical-shaped epithelial cells, mucus-producing and caveolin-1 (Cav-1)-expressing cells can be distinguished. Occasionally, the cuboidal-shaped cells also express Cav-1, which suggests that they are precursors of both mucus-producing and Cav-1-expressing cells. Very virulent infectious bursal disease virus (IBDV) impedes the differentiation of Cav-1-expressing cells and shifts the differentiation of cuboidal cells towards mucus-producing cells. In control birds exclusively, the IFE surface shows a mucous membrane, but after IBDV infection, the surfaces of both IFE and FAE are also covered by a mucous membrane. After IBDV infection, the cells of FAE also produce mucus, providing evidence for cell transformation. In late postinfection (pi; 28 d pi), the Cav-1 expression returned in the IFE cells, whereas the follicle (the primary lymphoid organ) underwent atrophy. The appearance of the renewed Cav-1-positive cells is similar to that of the normal basal cell, but they randomly locate in different levels of IFE, suggesting the loss of epithelial polarity. Between days 2 and 7 pi, the Cav-1 expression in the endothelial cells of the cortico-medullary capillary web is variable, which may explain the hemorrhage in several infected birds. The IBDV infection stops the Cav-1 expression and subsequently the cholesterol efflux into the bursal lumen. In the infected birds, the high cholesterol level may further worsen the clinical syndrome of IBDV.

AB - In the chicken bursa of Fabricius (BF), the interfollicular epithelium (IFE) consists of cylindrical- and cuboidal-shaped cells. Among the cylindrical-shaped epithelial cells, mucus-producing and caveolin-1 (Cav-1)-expressing cells can be distinguished. Occasionally, the cuboidal-shaped cells also express Cav-1, which suggests that they are precursors of both mucus-producing and Cav-1-expressing cells. Very virulent infectious bursal disease virus (IBDV) impedes the differentiation of Cav-1-expressing cells and shifts the differentiation of cuboidal cells towards mucus-producing cells. In control birds exclusively, the IFE surface shows a mucous membrane, but after IBDV infection, the surfaces of both IFE and FAE are also covered by a mucous membrane. After IBDV infection, the cells of FAE also produce mucus, providing evidence for cell transformation. In late postinfection (pi; 28 d pi), the Cav-1 expression returned in the IFE cells, whereas the follicle (the primary lymphoid organ) underwent atrophy. The appearance of the renewed Cav-1-positive cells is similar to that of the normal basal cell, but they randomly locate in different levels of IFE, suggesting the loss of epithelial polarity. Between days 2 and 7 pi, the Cav-1 expression in the endothelial cells of the cortico-medullary capillary web is variable, which may explain the hemorrhage in several infected birds. The IBDV infection stops the Cav-1 expression and subsequently the cholesterol efflux into the bursal lumen. In the infected birds, the high cholesterol level may further worsen the clinical syndrome of IBDV.

KW - caveolin-1

KW - IBDV infection

KW - interfollicular epithelium

KW - mucous membrane

KW - transformation of FAE and medullary reticular epithelial cell

UR - http://www.scopus.com/inward/record.url?scp=85066291665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066291665&partnerID=8YFLogxK

U2 - 10.3382/ps/pey512

DO - 10.3382/ps/pey512

M3 - Article

C2 - 30481345

AN - SCOPUS:85066291665

VL - 98

SP - 3464

EP - 3470

JO - Poultry Science

JF - Poultry Science

SN - 0032-5791

IS - 9

ER -