Effect of hyperlipidemia on QT dispersion in patients without ischemic heart disease

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Abstract

Background: Lipoproteins are known to exert direct and indirect effects on cardiovascular function, but their effects on ventricular repolarization have not yet been clearly elucidated. Objectives: To assess the effect of hyperlipidemia on the longest QT interval (QTmax) of the 12-lead surface electrocardiogram (ECG) and on QT dispersion (QTd) in type IIb hyperlipidemic patients without myocardial ischemia, and to compare these patients with healthy control subjects. Methods: Ninety-six hyperlipidemic patients (44 men and 52 women; mean age 53±13 years) and 101 healthy control subjects (43 men and 58 women; mean age 46±16 years) were examined. Total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride, apolipoprotein (apo) A1, apo B, lipoprotein(a), QTmax and QTd were measured. According to heart rate, corrected QTmax and corrected QTd were also determined. Results: A significant difference was observed between the two groups of subjects with respect to serum cholesterol, LDL-C, triglyceride, apo B, QTmax, corrected QTmax, QTd and corrected QTd. A positive significant correlation was found between cholesterol, triglyceride, LDL-C and all of the studied ECG parameters, between high density lipoprotein cholesterol and QTmax, apo B and QTd, and between body mass index and all of the studied ECG markers. Conclusions: Hyperlipidemia may have a direct effect on the studied ECG markers.

Original languageEnglish
Pages (from-to)847-850
Number of pages4
JournalCanadian Journal of Cardiology
Volume21
Issue number10
Publication statusPublished - Aug 1 2005

Keywords

  • Hyperlipidemia
  • Ionic channels
  • QT dispersion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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