Effect of hydrocortisone 17-butyrate on the percutaneous absorption of antibiotics

N. Simon, A. Dobozy

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Abstract

Absorption of antibiotics from combined preparations containing Oxytetracycline, chlortetracycline, doxycycline or gentamicin and hydrocortisone 17-butyrate into the skin of rats was examined. The penetration of antibiotics from the ointment into the skin was inhibited by 0.2% hydrocortisone 17-butyrate to a significant degree. It is suggested that this effect of hydrocortisone 17-butyrate is the consequence of its vasoconstrictor action.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalDermatology
Volume152
Issue numberSupplement 01
DOIs
Publication statusPublished - Jan 1 1976

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Keywords

  • Chlortetracycline
  • Doxycycline
  • Gentamicin
  • Hydrocortisone 17-butyrate
  • Oxytetracycline
  • Percutaneous absorption

ASJC Scopus subject areas

  • Dermatology

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