Effect of H1 and H2 agonists on the chemiluminescence of human blood mononuclear cells induced by phytohaemagglutinin

Katalin Meretey, M. Fekete, Ute Bohm, A. Falus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Previous results have shown a dose-dependent inhibition of the phytohaemagglutinin-elicited chemiluminescent response by histamine on human peripheral blood mononuclear cells (PBMs). The aim of the present experiments was to investigate the receptor specificity of this histamine action. The order of effectiveness of different histaminergic agonists was 4-methylhistamine > histamine = impromidine > dimaprit a ̊ 2-methylhistamine > 2-pyridylethylamine. Cimetidine inhibited and mepyramine enhanced this effect of histaminergic agonists. The results are consistent with the view that histamine inhibits the chemiluminescent reaction of PBMs via H2 receptors. Histamine in low doses (10-8 to 10-10 M) stimulated the chemiluminescent reaction. Cimetidine enhanced the chemiluminescence-facilitatory action of histamine and unmasked that of 2-pyridylethylamine. It is concluded that histamine is a possible humoral modulator of PBM activity: it is inhibitory via H2 receptors.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalImmunopharmacology
Volume9
Issue number3
DOIs
Publication statusPublished - 1985

Fingerprint

Histamine Agonists
Phytohemagglutinins
Luminescence
Histamine
Blood Cells
Histamine H2 Receptors
Cimetidine
Impromidine
Dimaprit
Pyrilamine
Histamine Receptors
phytobacteriomycin

Keywords

  • Chemiluminescence
  • Histamine
  • Mononuclear cells
  • Phytohemagglutinin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of H1 and H2 agonists on the chemiluminescence of human blood mononuclear cells induced by phytohaemagglutinin. / Meretey, Katalin; Fekete, M.; Bohm, Ute; Falus, A.

In: Immunopharmacology, Vol. 9, No. 3, 1985, p. 175-180.

Research output: Contribution to journalArticle

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AU - Falus, A.

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