The effect of H1 and H2 receptor‐blocking agents on antibody‐dependent cell‐mediated cytotoxicity (ADCC) was studied. The H1 receptor blocker clemastinum and the H2 receptor blocker cimetidine dose‐dependently inhibited the antibody‐dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor‐bearing effector cells in human ADCC is suggested.
|Number of pages||6|
|Journal||Scandinavian Journal of Immunology|
|Publication status||Published - Apr 1981|
ASJC Scopus subject areas