Effect of Histamine Receptor Blocking on Human Antibody‐dependent Cell‐mediated Cytotoxicity

I. LÁNG, K. TÖRÖK, P. GERGELY, K. NÉKÁM, GY PETRÁNYI

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Abstract

The effect of H1 and H2 receptor‐blocking agents on antibody‐dependent cell‐mediated cytotoxicity (ADCC) was studied. The H1 receptor blocker clemastinum and the H2 receptor blocker cimetidine dose‐dependently inhibited the antibody‐dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor‐bearing effector cells in human ADCC is suggested.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalScandinavian Journal of Immunology
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 1981

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ASJC Scopus subject areas

  • Immunology

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