Effect of hepatitis C infection on the quality of life

Gergely Horváth, Teodóra Keleti, Mihály Makara, Gabor S. Ungvari, G. Gazdag

Research output: Contribution to journalArticle


Purpose: To assess the quality of life (QoL) of patients with hepatitis C infection (HCI) and its correlations with demographic and clinical variables. Design and Methods: QoL and depressive symptoms were evaluated with the validated rating instruments of the 36-item short form (SF-36) generic health survey and the second version of the self-rated Beck depression inventory (BDI-II) in a cross-sectional design and correlated with basic demographic and clinical variables, including the Fibroscan score, which indicates the severity of liver impairment. Findings: A cohort of 60 HCI patients who participated in the study scored lower than the general population on all domains of the SF-36. In the multivariate correlation analysis, only the physical functioning domain of the SF-36 showed a significant correlation with age, gender, and BD-II and Fibroscan scores. Implications for Clinical Practice: QoL is lower for patients who are older, female, and have depressive symptoms. Progression of hepatic cirrhosis is associated with lower QoL in the physical domain.

Original languageEnglish
JournalPerspectives in Psychiatric Care
Publication statusAccepted/In press - Jan 1 2018


  • Cirrhosis
  • Depression
  • Hepatitis C
  • Quality of life

ASJC Scopus subject areas

  • Phychiatric Mental Health

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