Effect of Helicobacter pylori infection on epidermal growth factor receptor (EGFR) expression and cell proliferation of gastric epithelial mucosa: Correlation to macroscopic and microscopic diagnosis

Agnes Ruzsovics, Zsuzsa Unger, Bela Molnar, Laszlo Pronai, Zsolt Tulassay

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Our aim was to compare the expression of EGFR and proliferative cell nuclear antigen (PCNA) in different histological and endoscopic diagnostic groups, in cases of Helicobacter pylori infection, in vivo. Paraffin embedded human gastric biopsy samples (86) were analysed by EGFR and PCNA immunohistochemistry and classified both on the basis of histology and endoscopic findings. In normal epithelia (NE), a positive correlation was found between PCNA and EGFR and in H. pylori-negative gastritis with and without intestinal metaplasia (P < 0.01). On the other hand, a negative correlation was detected between the two immunohistochemical findings in H. pylori-associated gastritis with intestinal metaplasia (HPGIM) and in the atrophic gastritis (AG) group. In HPGIM the percentage of EGFR-positive cells was significantly lower (32.4 ± 30.4) when compared to either the NE (50.3 ± 23.7) or H. pylori-negative gastritis with intestinal metaplasia (HNGIM) (48.3 ± 23.7). In AG, EGFR was significantly lower when compared to the NE (P < 0.05). Based on the endoscopic findings, a significant decrease of EGFR expression was found in gastric ulcer cases as compared to NE, gastritis or erosion cases (P < 0.01). PCNA showed no significant alterations between the NE and gastritis, AG groups. The presence of H. pylori has an inverse effect on PCNA and EGFR expression in HPGIM.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalInternational Journal of Experimental Pathology
Volume83
Issue number5
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Endoscopic diagnosis
  • Epidermal growth factor receptor
  • Helicobacter pylori infection
  • Histological diagnosis
  • Intestinal metaplasia
  • Proliferative cell nuclear antigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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