Effect of heavy metals on the serotonin and dopamine systems in the central nervous system of the freshwater mussel (Anodonta cygnea L.)

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Abstract

1. 1. Heavy metals influencing the filtering behaviour of mussels cause alterations in the serotonergic and dopaminergic systems in the central nervous system of Anodonta cygnea both in in vivo and in in vitro conditions. 2. 2. Forty hours exposure of the animals to CdCl2 and ZnCl2 caused a transient parallel decrease in 5-HT and DA levels of the ganglia. Also CuCl2, HgCl2 and PbCl2 lowered 5-HT and DA concentrations during treatment; restoration of 5-HT level was rapid, while that of the DA concentration lasted for several days. 3. 3. In isolated ganglia, uptake of 5-HT and DA was inhibited only at high (10-4 mol/l) heavy metal concentrations; only CuCl2 caused 60% depression of DA uptake in 10-5 mol/l. 4. 4. Release of monoamines was influenced in a different way: both spontaneous and K-induced 5-HT release were depressed by Zn but were enhanced by Cu, Hg and Pb ions. Spontaneous DA release was enhanced by Cu, while K-induced DA release was increased by Cd, Cu and Zn ions; Hg depressed both. 5. 5. The results give further evidence that heavy metals influence mussels' behaviour by influencing the onoamine systems of the brain. The mechanism, however, has not yet been clarified.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume95
Issue number2
DOIs
Publication statusPublished - 1990

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Anodonta
Bivalvia
Heavy Metals
Fresh Water
Dopamine
Serotonin
Central Nervous System
Ganglia
Ions
Cadmium Chloride
Mercuric Chloride
Brain

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

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title = "Effect of heavy metals on the serotonin and dopamine systems in the central nervous system of the freshwater mussel (Anodonta cygnea L.)",
abstract = "1. 1. Heavy metals influencing the filtering behaviour of mussels cause alterations in the serotonergic and dopaminergic systems in the central nervous system of Anodonta cygnea both in in vivo and in in vitro conditions. 2. 2. Forty hours exposure of the animals to CdCl2 and ZnCl2 caused a transient parallel decrease in 5-HT and DA levels of the ganglia. Also CuCl2, HgCl2 and PbCl2 lowered 5-HT and DA concentrations during treatment; restoration of 5-HT level was rapid, while that of the DA concentration lasted for several days. 3. 3. In isolated ganglia, uptake of 5-HT and DA was inhibited only at high (10-4 mol/l) heavy metal concentrations; only CuCl2 caused 60{\%} depression of DA uptake in 10-5 mol/l. 4. 4. Release of monoamines was influenced in a different way: both spontaneous and K-induced 5-HT release were depressed by Zn but were enhanced by Cu, Hg and Pb ions. Spontaneous DA release was enhanced by Cu, while K-induced DA release was increased by Cd, Cu and Zn ions; Hg depressed both. 5. 5. The results give further evidence that heavy metals influence mussels' behaviour by influencing the onoamine systems of the brain. The mechanism, however, has not yet been clarified.",
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AB - 1. 1. Heavy metals influencing the filtering behaviour of mussels cause alterations in the serotonergic and dopaminergic systems in the central nervous system of Anodonta cygnea both in in vivo and in in vitro conditions. 2. 2. Forty hours exposure of the animals to CdCl2 and ZnCl2 caused a transient parallel decrease in 5-HT and DA levels of the ganglia. Also CuCl2, HgCl2 and PbCl2 lowered 5-HT and DA concentrations during treatment; restoration of 5-HT level was rapid, while that of the DA concentration lasted for several days. 3. 3. In isolated ganglia, uptake of 5-HT and DA was inhibited only at high (10-4 mol/l) heavy metal concentrations; only CuCl2 caused 60% depression of DA uptake in 10-5 mol/l. 4. 4. Release of monoamines was influenced in a different way: both spontaneous and K-induced 5-HT release were depressed by Zn but were enhanced by Cu, Hg and Pb ions. Spontaneous DA release was enhanced by Cu, while K-induced DA release was increased by Cd, Cu and Zn ions; Hg depressed both. 5. 5. The results give further evidence that heavy metals influence mussels' behaviour by influencing the onoamine systems of the brain. The mechanism, however, has not yet been clarified.

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