Effect of granulocyte colony-stimulating factor on granulopoiesis of congenital neutropenic children

I. Benko, L. Maródi, A. Megyeri, R. Káposzta, P. Kovács

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Abstract

We report on two patients with congenital neutropenia, who were treated with filgrastim (recombinant human granulocyte-colony stimulating factor, G-CSF). A poor growth of bone marrow colonies and low sensitivity of colony forming units to colony stimulating factor in vitro before treatment seemed to be associated with a requirement for higher doses of G-CSF to achieve good clinical response in vivo.

Original languageEnglish
Pages (from-to)261-262
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - Dec 1 1996

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Keywords

  • CFU-GM
  • Congenital neutropenia
  • G-CSF

ASJC Scopus subject areas

  • Physiology (medical)

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