Effect of glutathione depletion on electrophysiological characteristics of guinea-pig ventricles

P. Pacher, V. Kecskeméti, R. Feikai, T. Tószegi, B. Matkovics, M. Paróczai

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1 Citation (Scopus)


In this study the effect of acute and chronic glutathione depletion with L-buthionine-S,R-sulphoximine (BSO) on action potential characteristics of guinea-pig left ventricle papillary muscles were investigated. BSO caused significant decrease of maximum rate in rise of depolarization phase (Vmax) and duration of AP (APD) at 25%, 50%, 90% of repolarization in both cases of depletion and a slight but not significant decrease in the action potential amplitude, but did not modify the resting membrane potential. Pretreatment with bisaramil prevented the effect of BSO on APD in both cases of depletion.

Original languageEnglish
Pages (from-to)319-321
Number of pages3
JournalActa physiologica Hungarica
Issue number3
Publication statusPublished - Dec 1 1996



  • Action potential
  • BSO
  • Depletion
  • Glutathione

ASJC Scopus subject areas

  • Physiology (medical)

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