Effect of glutathione depletion on electrophysiological characteristics of guinea-pig ventricles

P. Pacher, V. Kecskeméti, R. Feikai, T. Tószegi, B. Matkovics, M. Paróczai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study the effect of acute and chronic glutathione depletion with L-buthionine-S,R-sulphoximine (BSO) on action potential characteristics of guinea-pig left ventricle papillary muscles were investigated. BSO caused significant decrease of maximum rate in rise of depolarization phase (Vmax) and duration of AP (APD) at 25%, 50%, 90% of repolarization in both cases of depletion and a slight but not significant decrease in the action potential amplitude, but did not modify the resting membrane potential. Pretreatment with bisaramil prevented the effect of BSO on APD in both cases of depletion.

Original languageEnglish
Pages (from-to)319-321
Number of pages3
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

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pamidronate
Glutathione
Guinea Pigs
Action Potentials
Papillary Muscles
Membrane Potentials
Heart Ventricles
buthionine

Keywords

  • Action potential
  • BSO
  • Depletion
  • Glutathione

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of glutathione depletion on electrophysiological characteristics of guinea-pig ventricles. / Pacher, P.; Kecskeméti, V.; Feikai, R.; Tószegi, T.; Matkovics, B.; Paróczai, M.

In: Acta Physiologica Hungarica, Vol. 84, No. 3, 1996, p. 319-321.

Research output: Contribution to journalArticle

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AU - Matkovics, B.

AU - Paróczai, M.

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